More people who received the Moderna vaccine, compared with the Pfizer-BioNTech vaccine, reported reactions, especially after the second dose.ĭr. Side effects were "substantially greater" after the second dose for both vaccines: over 50% experienced fatigue, 40% had headaches and over 30% had chills. ![]() Data collected from nearly 2 million participants who received both doses showed that the most frequently reported local and systemic reactions after the first dose was injection site pain and fatigue. Participants of V-safe self-enroll and self-report systemic reactions from the day of vaccination through a year after their final dose of the vaccine. Recent research published in the medical journal JAMA, analyzed side effects reported by people participating in the Centers for Disease Control and Prevention's V-safe surveillance system. Some have also experienced mild skin reactions, like delayed redness at the injection site. ![]() In some rare cases, people have experienced anaphylactic reactions to the vaccine.
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